The "Thunder Project" is a prospective observational study led by Academician Nanshan Zhong and AnchorDx in collaboration with 23 clinical centers. It seeks to enroll 10,560 participants with 5-30 mm pulmonary nodules. All participants will be followed up for 2~3 years. The clinical information, blood sample, CT/LDCT scan DICOM data, diagnostic report and/or pathological diagnosis report, and FFPE tissue sample of each participant will be collected at each visit. The purpose of this study is to comprehensively evaluate the performance and clinical value of the combined model of clinical, AI-assisted CT/LDCT imaging, and NGS-based ctDNA methylation biomarkers for the differential diagnosis and monitoring of benign and malignant pulmonary nodules.

This study was launched in September 2018, and the enrolment of  10,560 subjects were completed in May 2021. Follow-up studies are now being conducted in an orderly manner. The study protocol was published in Translational Lung Cancer Research, an internationally renowned academic journal, in November 2020, attracting widespread attention and recognition from the international medical and academic communities.

Follow-up study

ClinicalTrials.gov Identifier: NCT03651986